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Table 2 Multivariate linear mixed model with MMSE score as the dependent variable

From: Impact of cumulative exposure to anticholinergic and sedative drugs on cognition in older adults: a memory clinic cohort study

Parameters

Estimate

Test (df)

p value

DBI

 No exposure

Ref

-

-

 Moderate exposure

0.61

1.97 (2839.00)

0.049

 High exposure

0.34

0.80 (568.89)

0.423

Age

-0.01

-0.86 (5737.85)

0.388

Follow-up length (years)

-1.26

-9.25 (5000.95)

 < 0.001

Anxiety disorders

0.94

1.07 (39.56)

0.290

Depressive disorders

1.94

3.23 (211.88)

0.001

Educational level

 Secondary and further

Ref

-

-

 Primary

-1.95

-7.87 (138.96)

 < 0.001

 None

-4.13

-13.58 (259.15)

 < 0.001

IADL

0.89

18.87 (766.47)

 < 0.001

NPI

-0.01

-1.41 (71.19)

0.163

Follow-up length x DBI

 No exposure

Ref

-

-

 Moderate exposure

-0.48

-2.84 (2005.59)

0.005

 High exposure

-0.44

-3.51 (4759.00)

 < 0.001

  1. DBI Drug Burden Index, df degree of freedom, IADL Instrumental Activities of Daily Living, NPI Neuropsychiatric Inventory