18F-FDG PET can effectively rule out conversion to dementia and the presence of CSF biomarker of neurodegeneration: a real-world data analysis

Table 2 Diagnostic performance of brain ¹⁸F-FDG PET in predicting CSF biomarker patterns

	PET scans showing a neurodegenerative pattern	PET scans showing an Alzheimer’s disease pattern
A+
Se	76%	31%
Sp	38%	91%
PPV	52%	75%
NPV	63%	69%
Acc	56%	62%
T+
Se	74%	26%
Sp	44%	94%
PPV	76%	92%
NPV	42%	35%
Acc	66%	46%
N+
Se	86%	29%
Sp	33%	81%
PPV	14%	17%
NPV	95%	90%
Acc	39%	75%
A+/T+
Se	81%	38%
Sp	38%	90%
PPV	40%	67%
NPV	79%	73%
Acc	52%	72%

Data from patient medical records (N = 61). Abbreviations: Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; Acc, accuracy; A for amyloid biomarker, T for tau biomarker and N for neurodegeneration biomarker

ISSN: 1758-9193