Table 2 Univariable and multivariable regression analysis for BF volume
Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
Variable | Estimate (SE)* | Pvalue | Estimate (SE)* † | Pvalue |
CHIPSt group | ||||
CHIPSt1 | Reference | NA | Reference | NA |
CHIPSt2 | -0.03 (0.09) | 0.72 | -2.86 (0.09) | 0.71 |
CHIPSt3 | -0.29 (0.09) | < 0.01 | -24.51 (0.10) | 0.01 |
Age, years | -0.02 (0.01) | 0.03 | -10.43 (0.01) | 0.13 |
Female | 0.31 (0.08) | < 0.01 | 20.42 (0.11) | 0.04 |
Education, years | -0.02 (0.01) | < 0.01 | -13.59 (0.01) | 0.08 |
Hypertension | -0.05 (0.08) | 0.49 | NA | NA |
Diabetes mellitus | -0.29 (0.09) | < 0.01 | -21.74 (0.08) | < 0.01 |
Hyperlipidemia | 0.01 (0.08) | 0.92 | NA | NA |
Smoking | -0.22 (0.08) | 0.01 | -4.88 (0.10) | 0.59 |
Previous history of stroke | -0.28 (0.13) | 0.03 | -4.21 (0.12) | 0.54 |
Previous history of CAD | 0.04 (0.09) | 0.66 | NA | NA |
APOE ɛ4 carrier | 0.02 (0.11) | 0.87 | NA | NA |
Baseline MMSE | 0.01 (0.01) | 0.44 | NA | NA |
Deep WMH, Fazekas grade 2 or more | -0.11 (0.09) | 0.23 | NA | NA |
Periventricular WMH, Fazekas grade 3 | -0.20 (0.10) | 0.04 | 8.62 (0.11) | 0.29 |
Lacunes | -0.09 (0.09) | 0.33 | NA | NA |
Cerebral microbleeds | -0.20 (0.08) | 0.01 | -12.80 (0.08) | 0.07 |
Deep | -0.02 (0.02) | 0.25 | NA | NA |
Lobar | -0.01 (0.02) | 0.36 | NA | NA |
EPVS-BG | -0.04 (0.05) | 0.33 | NA | NA |
EPVS-CS | 0.07 (0.04) | 0.09 | NA | NA |
Total SVD scores | 0.05 (0.05) | 0.27 | NA | NA |