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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer’s disease

Fig. 1

Regional brain distribution of intranasally administered IRAs in CD-1 mice. Mean %Inj/g values 30 min after IN delivery represented in drawings of mid-sagittal sections. For dulaglutide in males, some regions (Olf Bulb, OC, Hy) exceeded the scale, indicated by hatch marks (see Supplemental Table 1 for %Inj/g value). The same scale bar (0-0.14%Inj/g) was used for each IRA to best compare against the other IRAs. n = 4/sex/region/IRA. Olf bulb = olfactory bulb, FC = frontal cortex, Str = striatum, Hy = hypothalamus, Thal = thalamus, PC = parietal cortex, OC = occipital cortex, Cereb = cerebellum, Mid Brain = midbrain, Pons/Med = pons/medulla

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Alzheimer's Research & Therapy

ISSN: 1758-9193