Fig. 3

Maximum IRA uptake in CD-1 mice following IN delivery. Maximum averages (%Inj/g or %Inj/ml) for males (closed bars) and females (open bars) are presented for (A) whole brain, (B) olfactory bulb, (C) neocortex, (D) hippocampus, (E) hypothalamus (IRA x sex p < 0.05), and (F) serum. Within each region, there was a significant difference between IRAs (p < 0.05). ANOVA within sex: ^±p < 0.05 vs. semaglutide, ^Ψp < 0.05 vs. dulaglutide, ^βp < 0.05 vs. DA4-JC, ^αp < 0.05 vs. DA5-CH. *p < 0.05 as marked within IRA. Exenatide n = 4 M/4F, semaglutide n = 3 M/5F, dulaglutide n = 4 M/4F, DA4-JC n = 4 F/4 M, DA5-CH n = 4 M/4F. M: male, F: female