Fig. 4
Saturability of 125I/14C-IRA brain uptake following IN delivery in CD-1 mice. 125I/14C-IRA was co-administered with (lighter bar) or without (darker bar) 1 µg non-radioactive IRA and %Inj/g or %Inj/ml calculated 30 min after delivery for (A) whole brain, (B) olfactory bulb, (C) frontal cortex/striatum, (D) hippocampus, (E) hypothalamus, and (F) serum. Unpaired t-test: *p < 0.05 as marked. Exenatide n = 3 M/2F per group, semaglutide n = 3 M/2F per group, dulaglutide n = 6 M per group, DA4-JC n = 3 M/4F per group, DA5-CH n = 4 M/5F per group. M: male, F: female