Fig. 6

Dulaglutide distribution in APP/PS1 female mice and WT littermate females following IN delivery. Distribution in (A) whole brain, (B) olfactory bulb, (C) neocortex (frontal + parietal + occipital), (D) hippocampus, (E) hypothalamus, and (F) serum. The ANOVA does not include the 15 min time point. ANOVA time *p < 0.05 for all regions; post hoc: ^bp<0.05 vs. 5 min, WT or APP/PS1 as indicated. ANOVA genotype and time by genotype in hippocampus p < 0.05; post hoc: ^#p < 0.05 as marked. See Supp Table 2 for additional statistical differences. n = 3–4/time point/genotype, except n = 0 for 15 min APP/PS1