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Table 3 Statistical results (p values) on dulaglutide brain distribution in APP/PS1 mice and WT littermates

From: Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer’s disease

 

Male

Female

Region

Time (T)

Genotype (G)

T x G

Time (T)

Genotype (G)

T x G

WB

0.041*

0.845

0.293

0.001*

0.379

0.177

Hc

0.038*

0.404

0.543

< 0.0001*

0.030*

0.012*

Neo

0.011*

0.241

0.447

< 0.0001*

0.830

0.18

OB

0.019*

0.103

0.757

0.047*

0.918

0.167

FC

0.005*

0.332

0.453

0.0004*

0.673

0.515

Str

0.001*

0.044*

0.043*

0.206

0.423

0.414

Hy

0.039*

0.184

0.676

0.002*

0.293

0.255

Th

0.001*

0.025*

0.116

< 0.0001*

0.073

0.005*

PC

0.041*

0.080

0.411

0.002*

0.299

0.067

OC

0.028*

0.357

0.442

0.014*

0.638

0.54

CB

0.239

0.667

0.533

0.320

0.635

0.622

MBr

0.129

0.953

0.721

0.197

0.326

0.55

Po

0.207

0.292

0.181

0.327

0.697

0.588

Ser

0.002*

0.228

0.637

< 0.0001*

0.634

0.409

  1. Mean %Inj/g or %Inj/ml levels ± SEM were compared within each sex and within each brain region with respect to time after IN delivery (5, 15, 30, or 60 min), genotype (APP/PS1 or WT), or the interaction between time and genotype (T x G). Overall ANOVA results are presented with statistical significance (*) defined as p < 0.05. n = 3–4/sex/genotype. Due to loss of female APP/PS1 mice, there is no data for the 15 min timepoint, and this timepoint was excluded in the ANOVA. Post-hoc analysis is reported in Supplemental Table 2. WB = whole brain, Hc = hippocampus, Neo = neocortex (frontal + parietal + occipital), OB = olfactory bulb, FC = frontal cortex, Str = striatum, Hy = hypothalamus, Th = thalamus, PC = parietal cortex, OC = occipital cortex, CB = cerebellum, MBr = midbrain, Po = pons/medulla, Ser = serum
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Alzheimer's Research & Therapy

ISSN: 1758-9193