Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer’s disease

Table 4 Statistical results (p values) for DA4-JC brain distribution in APP/PS1 mice and WT littermates

Mean %Inj/g or %Inj/ml levels ± SEM were compared within each sex and within each brain region with respect to time after IN delivery (5, 15, 30, or 60 min), genotype (APP/PS1 or WT), or the interaction between time and genotype (T x G). Overall ANOVA results are presented with statistical significance (*) defined as p < 0.05. n = 1–4/sex/genotype. Post-hoc analysis is reported in Supplemental Table 3. WB = whole brain, Hc = hippocampus, Neo = neocortex (frontal + parietal + occipital), OB = olfactory bulb, FC = frontal cortex, Str = striatum, Hy = hypothalamus, Th = thalamus, PC = parietal cortex, OC = occipital cortex, CB = cerebellum, MBr = midbrain, Po = pons/medulla, Ser = serum

ISSN: 1758-9193