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Table 3 Moderating effects of age, sex, APOE4, and clinical diagnosis on the association between each of protein intake categories and cognition

From: Protein intake and episodic memory: the moderating role of the apolipoprotein E ε4 status

 

Total score

Episodic memory score

Non-memory score

\(\:\varvec{\beta\:}\)

p

\(\:\varvec{\beta\:}\)

p

\(\:\varvec{\beta\:}\)

p

Model for age effect

      

Protein intake categories

 High

0.372

0.573

0.382

0.506

-0.646

0.419

 Medium

-0.556

0.411

0.012

0.983

-0.756

0.357

 Low

-

 

-

 

-

 

Age

-0.290

< 0.001

-0.264

< 0.001

-0.253

0.009

Protein intake categories\(\:\times\:\)Age

 High\(\:\:\times\:\) Age

-0.142

0.829

-0.201

0.725

0.751

0.345

 Medium \(\:\times\:\) Age

0.577

0.389

-0.040

0.945

0.750

0.356

 Low \(\:\times\:\) Age

-

 

-

 

-

 

Model for sex effect

      

Protein intake categories

 High

0.309

< 0.001

0.213

< 0.001

0.105

0.199

 Medium

-0.001

0.989

-0.067

0.247

-0.008

0.918

 Low

-

 

-

 

-

 

Sex

0.167

0.023

0.129

0.045

0.129

0.154

Protein intake categories\(\:\times\:\)Sex

 High\(\:\:\times\:\) Sex

-0.114

0.080

-0.081

0.156

-0.132

0.092

 Medium \(\:\times\:\) Sex

0.019

0.804

0.076

0.261

-0.012

0.900

 Low \(\:\times\:\) Sex

-

 

-

 

-

 

Model for APOE4 effect

      

Protein intake categories

 High

0.165

0.014

0.084

0.143

0.030

0.716

 Medium

0.010

0.871

-0.050

0.336

-0.008

0.917

 Low

-

 

-

 

-

 

APOE4

-0.078

0.322

-0.108

0.111

-0.042

0.662

Protein intake categories\(\:\times\:\)APOE4

 High\(\:\:\times\:\) APOE4

0.073

0.307

0.146

0.018

0.100

0.253

 Medium \(\:\times\:\) APOE4

0.038

0.611

0.062

0.329

0.043

0.637

 Low \(\:\times\:\) APOE4

-

 

-

 

-

 

Model for clinical diagnosis effect

      

Protein intake categories

 High

0.252

< 0.001

0.159

0.006

0.147

0.067

 Medium

-0.049

0.525

-0.105

0.119

-0.036

0.701

 Low

-

 

-

 

-

 

Clinical diagnosis

-0.457

< 0.001

-0.630

< 0.001

-0.205

0.025

Protein intake categories\(\:\times\:\)Clinical diagnosis

 High\(\:\:\times\:\) Clinical diagnosis

-0.066

0.292

0.022

0.685

-0.096

0.207

 Medium \(\:\times\:\) Clinical diagnosis

0.117

0.194

0.127

0.105

0.062

0.569

 Low \(\:\times\:\) Clinical diagnosis

-

 

-

 

-

 
  1. APOE4 apolipoprotein ε4, GDS geriatric depression scale, VRS vascular risk score
  2. By multiple logistic regression analysis controlling for age, sex, apolipoprotein ε4, education, clinical diagnosis, VRS, GDS score, annual income, physical activity, fruit/vegetable, fasting glucose, and HDL- or LDL- cholesterol as covariates when appropriate