Table 1 Baseline characteristics of participants

N(%)

545

204(37.43)

341(62.57)

Age, year, mean ± SD

72.6 ± 6.9

73.6 ± 5.8

72.07 ± 7.41

0.136

Sex, Female (%)

232 (42.57)

100(49.02)

132(38.71)

0.165

Education years, mean ± SD

14.5 ± 3.1

14.61 ± 3.08

14.39 ± 3.09

0.290

ApoE ε4 carriers, n (%)

234 (42.9)

56(27.45)

178(52.20)

< 0.001

MDSs, n (%)

364(66.79)

110(53.92)

254(74.49)

< 0.001

ADAS13 score, mean ± SD

12.0 ± 5.5

9.09 ± 4.20

13.72 ± 5.44

< 0.001

MMSE score, mean ± SD

28.15 ± 1.81

29.04 ± 1.21

27.56 ± 1.90

< 0.001

ADNI_MEM score, mean ± SD

0.383 ± 0.829

0.91 ± 0.67

0.71 ± 0.76

< 0.001

ADNI_EF score, mean ± SD

0.309 ± 0.973

0.70 ± 0.90

0.74 ± 0.94

< 0.001

CDR score

(0,0.5)

0

0.5

< 0.001

CSF sTREM2 Mean ± SD

3554.9 ± 2121.2

3798.9 ± 2123.7

3408.83 ± 2109.36

0.115

CSF biomarkers and ratios, mean ± SD

Aβ42 pg/mL

552.4 ± 297.3

685.02 ± 239.5

473.11 ± 270.42

< 0.001

A + T+

198(36.33)

55(26.96)

143(41.94)

< 0.001

Tau pg/mL

134.6 ± 59.2

122.6 ± 41.9

141.85 ± 66.45

0.028

pTau pg/mL

27.4 ± 16.4

22.98 ± 13.07

30.06 ± 17.58

0.003

Tau/Aβ42 ratio

0.367 ± 0.332

0.23 ± 0.19

0.45 ± 0.37

< 0.001

pTau /Aβ42 ratio

0.826 ± 0.927

0.05 ± 0.06

0.10 ± 0.10

< 0.001

Brain structure, mean ± SD

HV (mm³)

7034.62 ± 1132.665

7484.16 ± 889.7

6751.01 ± 1178.13

< 0.001

EC thickness (mm³)

3448.68 ± 1005.687

3804.8 ± 773.5

3225.07 ± 1069.46

< 0.001

Ventricular volume (mm³)

34910.99 ± 22676.354

29712.7 ± 19051.2

37947.30 ± 24059.88

0.001