Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy

Table 2 Comparison of structural and flow parameters between participants with PCA and healthy control participants

Parameters	Participants with PCA	Healthy control participants	P value*
ORT
0–1 mm	185.81 ± 17.23	189.58 ± 16.75	0.171
1–3 mm	168.35 ± 10.27	173.53 ± 10.10	0.002
3–6 mm	143.53 ± 9.28	149.57 ± 8.35	< 0.001
Total	150.31 ± 9.04	156.02 ± 8.23	< 0.001
CRT
0–1 mm	283.06 ± 111.29	325.04 ± 132.25	0.036
1–3 mm	275.47 ± 107.81	315.60 ± 126.17	0.041
3–6 mm	252.50 ± 92.60	293.97 ± 110.96	0.017
Total	258.54 ± 96.06	299.65 ± 114.28	0.021
choriocapillaris VD
0–1 mm	68.87 ± 7.91	71.46 ± 8.46	0.041
1–3 mm	67.39 ± 5.29	69.85 ± 5.41	0.007
3–6 mm	69.05 ± 3.51	70.03 ± 3.12	0.082
Total	68.68 ± 3.54	70.04 ± 3.09	0.019
CVI
0–1 mm	0.35 ± 0.07	0.37 ± 0.08	0.212
1–3 mm	0.35 ± 0.05	0.38 ± 0.06	0.005
3–6 mm	0.30 ± 0.11	0.36 ± 0.14	0.019
Total	0.31 ± 0.15	0.37 ± 0.19	0.045
CVV
0–1 mm	0.08 ± 0.03	0.09 ± 0.03	0.002
1–3 mm	0.62 ± 0.23	0.72 ± 0.22	0.009
3–6 mm	1.69 ± 0.67	2.49 ± 0.63	0.002
Total	2.39 ± 0.92	2.85 ± 0.87	0.003

Abbreviations: PCA, Posterior cortical atrophy; ORT, outer retina thickness(µm); CRT, choroid thickness(µm); VD, vessel density (%); CVI, choroidal vascular index; CVV, choroidal vascular volume
^*P value was based on GEE adjusted for the inter-eye correlation, age, sex and signal strengths. Bonferroni correction was applied to adjust for multiple comparisons, with P values < 0.0125 were considered statistically significant

ISSN: 1758-9193