Fig. 4

Plasma P-tau217 is Significantly Correlated with Plasma GFAP, Plasma Total-tau and CSF Total-tau in Aβ + Individuals. Plasma and CSF samples were additionally analysed for Glial Fibrillary Acidic Protein (GFAP), Neurofilament Light (NfL) and Total tau (t-tau). A (i) Plasma GFAP significantly differed between Aβ + vs Aβ- individuals (U = 811, p = 0.004) (i-vi) None of the additional markers differed in Aβ + vs Aβ – individuals. B (i) Significant correlations were observed between plasma GFAP in Aβ + but not Aβ – individuals. (ii, v) No correlations were seen between plasma or CSF NfL and plasma p-tau217. (iv) CSF GFAP did not correlate with plasma p-tau217. (iii, vi) Significant correlations were seen between plasma p-tau217 and both plasma and CSF t-tau in Aβ + but not Aβ – individuals. ****p < 0.0001, ***p < 0.001, ** < 0.01, *p < 0.05, ns: non-significant