Neurodegenerative biomarkers in different chambers of the eye relative to plasma: an agreement validation study

Table 3 Correlation analysis of the biomarkers’ relative concentrations between eye fluids and plasma

	Aβ40		Aβ42		t-Tau		ptau181		GFAP		NfL
Comparison	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value
Vitreous—Plasma	0.10	0.42	0.14	0.27	0.36	0.004*	0.17	0.18	0.06	0.6	0.33	0.006*
Aqueous—Plasma	0.26	0.12	0.26	0.12	-0.09	0.60	0.17	0.27	0.24	0.17	0.49	0.004*
Tears—Plasma	0.50	0.02*	0.34	0.13	0.08	0.74	0.11	0.49	NA	NA	NA	NA

Spearman’s rank correlations coefficients rho (R) and P values for eye fluids against plasma. ‘*’ indicates statistical significance with P value lower or equal to 0.05. Aβ: amyloid beta; t-Tau: total tau; ptau181: hyperphosphorylated tau 181; GFAP: Glial fibrillary acidic protein; NfL: neurofilament light chain

ISSN: 1758-9193