Neurodegenerative biomarkers in different chambers of the eye relative to plasma: an agreement validation study

Table 4 Correlation analysis of the biomarkers’ relative concentrations across inter-eye chamber fluids

	Aβ40		Aβ42		t-Tau		ptau181		GFAP		NfL
Comparison	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value	R-value	P-value
Vitreous—Aqueous	0.11	0.49	0.10	0.52	0.47	0.001*	0.28	0.05	0.60	< 0.001*	0.68	< 0.001*
Vitreous—Tears	-0.19	0.34	-0.16	0.45	0.16	0.43	-0.19	0.17	NA	NA	NA	NA
Tears—Aqueous	0.31	0.37	0.16	0.64	0.23	0.49	0.02	0.91	NA	NA	NA	NA

Spearman’s rank correlations coefficients rho (R) and P values for inter-eye chamber fluids. ‘*’ indicates statistical significance with P value lower or equal to 0.05. Aβ amyloid beta, t-Tau total tau, ptau181 hyperphosphorylated tau 181, GFAP Glial fibrillary acidic protein, NfL neurofilament light chain

ISSN: 1758-9193