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Table 5 Agreement analysis of the biomarkers’ relative concentrations between eye fluids and plasma

From: Neurodegenerative biomarkers in different chambers of the eye relative to plasma: an agreement validation study

 

Aβ40

Aβ42

t-Tau

ptau181

GFAP

NfL

Comparison

Bias

95% LOA

Bias

95% LOA

Bias

95% LOA

Bias

95% LOA

Bias

95% LOA

Bias

95% LOA

Aqueous—Plasma

229.2

504.7

8.5

18.0

-14.2

142.0

-7.2

47.4

-1796.4

13,296.8

-16.5

762.0

Vitreous—Plasma

-258.6

1079.7

-18.6

63.6

-33.3

319.7

-11.7

42.0

-17,863.1

87,989.4

-364.9

3517.7

Tears—Plasma

311.0

11.2

12.2

1.9

-89.9

383.9

-31.2

200.7

NA

NA

NA

NA

  1. Bland–Altman agreement analysis, showing bias (mean difference) and 95% limits of agreement (LOA) between pairwise differences in levels of eye-fluid biomarker and magnitude of plasma biomarker. Aβ amyloid beta, t-Tau total tau, ptau181 hyperphosphorylated tau 181, GFAP Glial fibrillary acidic protein, NfL neurofilament light chain