Table 2 Associations between glycemic status and risk of all-cause mortality in individuals with dementia
Group | Dementia (n) | Mortality (n) | Person-years | Mortality rate* | HR (95% CI)† | |||
|---|---|---|---|---|---|---|---|---|
Model 1‡ | Model 2§ | Model 3|| | ||||||
All-cause dementia | ||||||||
DM | No | 103,136 | 35,309 | 388,769 | 90.8 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 43,696 | 16,809 | 155,428 | 108.2 | 1.20 (1.18–1.22) | 1.35 (1.32–1.37) | 1.34 (1.32–1.37) | |
Glycemic status | Normoglycemia | 67,771 | 23,386 | 256,459 | 91.2 | 1 (reference) | 1 (reference) | 1(reference) |
Prediabetes | 35,365 | 11,923 | 132,310 | 90.1 | 0.99 (0.97–1.01) | 1.03 (1.00–1.05) | 1.03 (1.01–1.05) | |
New-onset DM | 8,066 | 3,545 | 27,215 | 130.3 | 1.45 (1.40–1.50) | 1.35 (1.30–1.40) | 1.35 (1.30–1.40) | |
Known DM | 35,630 | 13,264 | 128,213 | 103.5 | 1.14 (1.12–1.17) | 1.36 (1.33–1.39) | 1.36 (1.33–1.39) | |
Glycemic status and duration of DM | Normoglycemia | 67,771 | 23,386 | 256,459 | 91.2 | 1 (reference) | 1 (reference) | 1 (reference) |
Prediabetes | 35,365 | 11,923 | 132,310 | 90.1 | 0.99 (0.97–1.01) | 1.03 (1.01–1.05) | 1.03 (1.01–1.05) | |
New-onset DM | 8,066 | 3,545 | 27,215 | 130.3 | 1.45 (1.40–1.50) | 1.35 (1.30–1.40) | 1.35 (1.30–1.40) | |
DM < 5 years | 9,247 | 3,104 | 36,231 | 85.7 | 0.94 (0.90–0.97) | 1.17 (1.13–1.21) | 1.17 (1.13–1.21) | |
DM ≥ 5 years | 26,383 | 10,160 | 91,983 | 110.5 | 1.23 (1.20–1.26) | 1.43 (1.40–1.47) | 1.43 (1.40–1.47) | |
Alzheimer’s disease | ||||||||
DM | No | 72,979 | 25,247 | 271,812 | 92.9 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 30,465 | 11,741 | 107,012 | 109.7 | 1.19 (1.17–1.22) | 1.35 (1.32–1.38) | 1.34 (1.31–1.37) | |
Glycemic status | Normoglycemia | 47,785 | 16,721 | 178,674 | 93.6 | 1 (reference) | 1 (reference) | 1 (reference) |
Prediabetes | 25,194 | 8,526 | 93,138 | 91.5 | 0.98 (0.96–1.01) | 1.03 (1.00–1.05) | 1.03 (1.00–1.05) | |
New-onset DM | 5,731 | 2,527 | 19,154 | 131.9 | 1.43 (1.37–1.49) | 1.34 (1.29–1.40) | 1.34 (1.29–1.40) | |
Known DM | 24,734 | 9,214 | 87,857 | 104.9 | 1.13 (1.10–1.16) | 1.36 (1.33–1.40) | 1.36 (1.32–1.40) | |
Glycemic status and duration of DM | Normoglycemia | 47,785 | 16,721 | 178,674 | 93.6 | 1 (reference) | 1 (reference) | 1 (reference) |
Prediabetes | 25,194 | 8,526 | 93,138 | 91.5 | 0.98 (0.96–1.01) | 1.03 (1.00–1.05) | 1.03 (1.00–1.05) | |
New-onset DM | 5,731 | 2,527 | 19,154 | 131.9 | 1.43 (1.37–1.49) | 1.34 (1.29–1.40) | 1.34 (1.29–1.40) | |
DM < 5 years | 6,227 | 2,117 | 24,145 | 87.7 | 0.93 (0.89–0.98) | 1.18 (1.13–1.23) | 1.18 (1.13–1.23) | |
DM ≥ 5 years | 18,507 | 7,097 | 63,713 | 111.4 | 1.21 (1.17–1.24) | 1.43 (1.39–1.47) | 1.43 (1.39–1.47) | |
Vascular dementia | ||||||||
DM | No | 13,415 | 4,036 | 50,991 | 79.2 | 1 (reference) | 1 (reference) | 1 (reference) |
Yes | 6,113 | 2,200 | 21,774 | 101.0 | 1.29 (1.22–1.36) | 1.40 (1.33–1.48) | 1.39 (1.32–1.47) | |
Glycemic status | Normoglycemia | 8,937 | 2,668 | 34,224 | 78.0 | 1 (reference) | 1 (reference) | 1 (reference) |
Prediabetes | 4,478 | 1,368 | 16,767 | 81.6 | 1.05 (1.00–1.12) | 1.06 (1.00–1.13) | 1.06 (0.99–1.13) | |
New-onset DM | 1,001 | 411 | 3,312 | 124.1 | 1.62 (1.46–1.80) | 1.45 (1.31–1.61) | 1.45 (1.30–1.61) | |
Known DM | 5,112 | 1,789 | 18,461 | 96.9 | 1.25 (1.18–1.33) | 1.42 (1.33–1.51) | 1.41 (1.33–1.50) | |
Glycemic status and duration of DM | Normoglycemia | 8,937 | 2,668 | 34,224 | 78.0 | 1 (reference) | 1 (reference) | 1 (reference) |
Prediabetes | 4,478 | 1,368 | 16,767 | 81.6 | 1.05 (0.99–1.12) | 1.06 (0.99–1.13) | 1.06 (0.99–1.13) | |
New-onset DM | 1,001 | 411 | 3,312 | 124.1 | 1.62 (1.46–1.80) | 1.45 (1.31–1.61) | 1.45 (1.31–1.61) | |
DM < 5 years | 1,475 | 435 | 5,782 | 75.2 | 0.96 (0.87–1.06) | 1.17 (1.05–1.29) | 1.16 (1.05–1.29) | |
DM ≥ 5 years | 3,637 | 1,354 | 12,680 | 106.8 | 1.39 (1.30–1.48) | 1.52 (1.42–1.63) | 1.52 (1.42–1.63) | |