Fig. 10
From: Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer’s disease
Differential dynamics of PSD-95 in WT and APP/PS1 primary neuronal cultures. Representative images of neurites (a) and dendritic spines (e) showing pre-bleach, bleach, and post-bleach stages of PSD-95 fluorescence in WT and APP/PS1 neurite. (b, f) The plot illustrates the recovery of fluorescence intensity over time. (c, g) Mobile fraction and (d, h) halftime of recovery extracted from the fitted curve. Statistical comparison between groups were conducted using an unpaired, two-tailed t-test with Welch’s correction. Data are presented as mean ± SD (n = 16–18 cumulative from three independent experiments). Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Scale bar = 5 μm