Fig. 6
From: Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer’s disease
Jasplakinolide treatment restores F-actin levels and dendritic spine density in APP/PS1 neurites. (a) Representative images of WT and APP/PS1 primary cortical neuronal cultures treated with jasplakinolide and stained with phalloidin (F-actin), along with 3D reconstructions. (b) Quantification of F-actin levels from tertiary neurites. (c) Quantification of total dendritic spine density normalized to WT vehicle. (d) Quantification of number of spine/µm and (e) total number of spines observed. Statistical comparison between groups were conducted using two-way ANOVA followed by Tukey’s post test. Data are presented as mean ± SEM from three independent experiment (20 neurites from each independent experiment). Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Scale bar = 5 μm