Fig. 9
From: Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer’s disease
Frap experiments shows decreased actin recovery rate in primary cortical neuronal cultures co-expressed with PSD-95. (a) Representative images showing pre-bleach, bleach, and post-bleach stages of actin fluorescence when expressed alone and when co-expressed with PSD-95 in WT neurites. (b) The plot illustrates the recovery of fluorescence intensity over time. (c) Mobile fraction and (d) halftime of recovery extracted from the fitted curve. Statistical comparison between groups were conducted using an unpaired, two-tailed t-test with Welch’s correction. Data are presented as mean ± SD (n = 16–18 cumulative from three independent experiments). Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Scale bar = 5 μm