Table 1 CAIDE model variables of the study population (n = 5,360)
CAIDE model variables | No dementia (n = 4,950) | All-cause dementia (n = 410) | Alzheimer’s disease (n = 139) | Vascular dementia (n = 152) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Data | Data | p-valuea | Data | p-valuea | Data | p-valuea | ||||
Age (years), mean (SD) | 61.2 (6.4) | 66.9 (5.2) | < 0.001 | 66.7 (5.2) | < 0.001 | 66.9 (5.0) | < 0.001 | |||
Mid-life (50–64 years), n (%) | 3330 (67.3) | 128 (31.2) | 46 (33.1) | 47 (30.9) | ||||||
Late-life (65–75 years), n (%) | 1620 (32.7) | 282 (68.8) | 93 (66.9) | 105 (69.1) | ||||||
Education (years), n (%) | 0.001 | 0.036 | 0.135 | |||||||
≤9 | 3592 (72.6) | 331 (80.7) | 115 (82.7) | 122 (80.3) | ||||||
10–11 | 752 (15.2) | 38 (9.3) | 13 (9.4) | 16 (10.5) | ||||||
≥ 12 | 606 (12.2) | 41 (10.0) | 11 (7.9) | 14 (9.2) | ||||||
Sex, n (%) | 0.072 | 0.968 | 0.076 | |||||||
Female | 2680 (54.1) | 203 (49.5) | 75 (54.0) | 71 (46.7) | ||||||
Male | 2270 (45.9) | 207 (50.5) | 64 (46.0) | 81 (53.3) | ||||||
SBP (mmHg), mean (SD) | 138.9 (19.5) | 142.4 (19.2) | < 0.001 | 142.2 (19.2) | 0.046 | 142.8 (19.5) | 0.007 | |||
BMI (kg/m2), mean (SD) | 27.7 (4.4) | 27.6 (3.9) | 0.924 | 27.1 (3.8) | 0.304 | 27.7 (4.0) | 0.957 | |||
Total cholesterol (mmol/L), mean (SD) | 5.69 (1.3) | 5.69 (1.3) | 0.975 | 5.73 (1.3) | 0.545 | 5.68 (1.3) | 0.925 | |||
Physical activityb, n (%) | < 0.001 | 0.001 | 0.178 | |||||||
Inactive | 830 (16.8) | 108 (26.3) | 43 (30.9) | 34 (22.4) | ||||||
Low | 2284 (46.1) | 184 (44.9) | 57 (41.0) | 71 (46.7) | ||||||
Medium or high | 1836 (37.1) | 118 (28.8) | 39 (28.1) | 47 (30.9) | ||||||
APOE genotypes, n (%) | < 0.001 | < 0.001 | 0.014 | |||||||
ε4 non-carrier | 3710 (75.0) | 243 (59.3) | 69 (49.6) | 99 (65.1) | ||||||
ε4 carrier | 1240 (25.0) | 167 (40.7) | 70 (50.4) | 53 (34.9) | ||||||