Comparison of subjective cognitive decline and polygenic risk score in the prediction of all-cause dementia, Alzheimer’s disease and vascular dementia

Table 2 Associations between predictors of interest and common subtypes of dementia

Predictors	n_total	n_cases	Model 1^a		Model 2^b
Predictors	n_total	n_cases	HR (95% CI)	p-value	HR (95% CI)	p-value
All-cause dementia
SCD	5,360	410	1.49 (1.21–1.82)	< 0.001	1.48 (1.21–1.82)	< 0.001
Kunkle PRS per 1SD^c	5,360	410	1.22 (1.11–1.34)	< 0.001	1.03 (0.93–1.15)	0.350
Alzheimer’s disease
SCD	5,089	139	1.27 (0.89–1.83)	0.191	1.27 (0.88–1.83)	0.197
Kunkle PRS per 1SD^d	5,089	139	1.51 (1.29–1.76)	< 0.001	1.20 (1.00-1.43)	0.049
Vascular dementia
SCD	5,102	152	1.62 (1.16–2.25)	0.005	1.62 (1.16–2.25)	0.005
Kunkle PRS per 1SD^e	5,102	152	1.04 (0.88–1.23)	0.680	0.91 (0.76–1.09)	0.291

Note: Numbers printed in bold are statistically significant (P < 0.05)
Abbreviations: HR, hazard ratio; CI, confidence interval; SD, standard deviation; SCD, subjective cognitive decline; PRS, polygenic risk score;
^aModel 1 was adjusted for age, education, sex, systolic blood pressure, BMI, total cholesterol and physical activity
^bModel 2 was adjusted for all variables listed in Model 1 and APOE ε4 carrier status
^c1 SD of Kunkle’s PRS = 0.0100
^d1 SD of Kunkle’s PRS = 0.0010
^e1 SD of Kunkle’s PRS = 0.0099

ISSN: 1758-9193