Table 4 Evaluation of the discriminative ability for all-cause dementia in mid-life and late-life

^aMid-life (50–64 years)[n_total=3458, n_cases=128]

AIC

1930.1

1919.4

1925.5

1908.0

1908.7

1903.3

AUC (95% CI)

0.731

(0.692–0.771)

0.744

(0.704–0.784)

0.735

(0.696–0.774)

0.758

(0.718–0.797)

0.759

(0.719–0.799)

0.760

(0.720–0.800)

Reclassification

Events n_up/n_down

Ref.

25/21

23/24

Ref.

8/6

20/20

Nonevents n_up/n_down

Ref.

266/392

283/377

Ref.

106/112

260/321

NRI %^c (p-value)

Ref.

6.9% (0.008)

2.0%

(0.616)

Ref.

1.7%

(0.455)

1.8%

(0.631)

IDI % (p-value)

Ref.

0.03% (0.018)

0.02% (0.018)

Ref.

-0.0007% (0.798)

0.02% (0.021)

^bLate-life (65–75 years)[n_total=1902, n_cases=282]

AIC

3958.0

3955.4

3952.7

3935.5

3937.4

3930.4

AUC (95% CI)

0.673

(0.641–0.705)

0.678

(0.646–0.710)

0.678

(0.647–0.710)

0.697

(0.666–0.728)

0.697

(0.666–0.728)

0.699

(0.669–0.730)

Reclassification

Events n_up/n_down

Ref.

23/23

39/41

Ref.

1/2

24/35

Nonevents n_up/n_down

Ref.

98/127

180/182

Ref.

3/4

156/164

NRI %^d (p-value)

Ref.

1.8% (0.462)

-0.59% (0.851)

Ref.

-0.29% (0.531)

-3.4% (0.237)

IDI % (p-value)

Ref.

0.12% (0.119)

0.05% (0.031)

Ref.

-0.003% (0.874)

0.07% (0.023)