Table 5 Evaluation of the discriminative ability for Alzheimer’s disease in mid-life and late-life

^aMid-life (50–64 years)[n_total=3330, n_cases=46]

AIC

698.6

680.4

699.2

677.5

674.5

677.9

AUC (95% CI)

0.767

(0.705–0.829)

0.794

(0.734–0.854)

0.765

(0.703–0.827)

0.809

(0.743–0.875)

0.811

(0.747–0.875)

0.808

(0.743–0.873)

Reclassification

Events n_up/n_down

Ref.

12/6

5/2

Ref.

7/5

3/6

Nonevents n_up/n_down

Ref.

299/516

160/156

Ref.

175/230

113/119

NRI %^c (p-value)

Ref.

19.6% (0.008)

6.4% (0.163)

Ref.

6.0% (0.250)

-6.3% (0.110)

IDI % (p-value)

Ref.

0.02% (0.025)

-0.0006 (0.243)

Ref.

0.002% (0.239)

-0.001 (0.504)

^bLate-life (65–75 years)[n_total=1713, n_cases=93]

AIC

1306.4

1301.5

1307.7

1290.1

1291.7

1291.5

AUC (95% CI)

0.689

(0.633–0.745)

0.708

(0.652–0.764)

0.688

(0.633–0.744)

0.740

(0.688–0.791)

0.738

(0.686–0.791)

0.739

(0.687–0.790)

Reclassification

Events n_up/n_down

Ref.

16/15

4/9

Ref.

3/4

1/7

Nonevents n_up/n_down

Ref.

189/218

84/72

Ref.

40/51

65/88

NRI %^d (p-value)

Ref.

2.9% (0.595)

-6.1% (0.068)

Ref.

-4.0% (0.877)

-5.0% (0.101)

IDI % (p-value)

Ref.

0.06% (0.109)

-0.01% (0.683)

Ref.

0.01% (0.199)

-0.004% (0.390)