Table 6 Evaluation of the discriminative ability for vascular dementia in mid-life and late-life

Mid-life (50–64 years)[n_total=3377, n_cases=47]

AIC

707.6

709.3

709.4

708.9

710.9

710.8

AUC (95% CI)

0.757

(0.703–0.812)

0.759

(0.702–0.815)

0.758

(0.703–0.812)

0.762

(0.706–0.817)

0.761

(0.705–0.818)

0.762

(0.706–0.818)

Reclassification

Events n_up/n_down

Ref.

4/1

3/4

Ref.

4/1

5/3

Nonevents n_up/n_down

Ref.

99/99

115/110

Ref.

26/39

93/122

NRI %^c (p-value)

Ref.

6.38% (0.076)

-2.3% (0.554)

Ref.

6.8% (0.001)

5.1% (0.174)

IDI % (p-value)

Ref.

0.00007 (0.357)

-0.0005 (0.562)

Ref.

-0.0003 (0.451)

-0.0006 (0.588)

Late-life (65–75 years)[n_total=1725, n_cases=105]

AIC

1475.2

1477.2

1468.5

1469.4

1469.7

1462.9

AUC (95% CI)

0.669

(0.616–0.721)

0.669

(0.616–0.721)

0.694

(0.643–0.745)

0.683

(0.628–0.737)

0.683

(0.628–0.738)

0.702

(0.649–0.755)

Reclassification

Events n_up/n_down

Ref.

1/1

29/19

Ref.

12/3

25/17

Nonevents n_up/n_down

Ref.

9/3

283/334

Ref.

98/107

288/317

NRI %^d (p-value)

Ref.

-0.4% (0.683)

12.7% (0.043)

Ref.

9.1% (0.011)

9.4% (0.127)

IDI % (p-value)

Ref.

0.002% (0.911)

0.01% (0.134)

Ref.

-0.01% (0.444)

0.3% (0.088)