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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

Fig. 1

Summary of epitope diversity and antigen-binding characteristics of anti-tau antibodies generated from phage display libraries – (A) The scFv diversity generated through biopanning and their ability to bind regions along the length of the tau protein (2N4R tau). Number of unique clones representing various epitope regions of tau as determined by peptide ELISA. (B) Examples of relative immunoreactivity measurements of ten 367–379 AA specific scAbs binding to 2N4R tau (left panel) and six 391E specific scAbs binding to dGAE (right panel) in ELISA. The scAb with greatest immunoreactivity in each group was selected as the lead clone and is shown in green. (C) Schematic representation of the epitopes recognised by the final panel of lead scAbs. Differing colours of antibody are for presentation purposes only and to highlight the different epitope classes they bind.

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Alzheimer's Research & Therapy

ISSN: 1758-9193