Skip to main content
Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

Fig. 2

Determining key amino acids for antigen recognition of core-tau binders of interest - Percentage binding of CE2 (A) S1D12 (B) CA4 (C) S1G2 (D) scAbs to ASM peptides in relation to their respective parental peptide sequences. Critical amino acids for antibody binding are shown with red numbers in the inset image for each of the four clones (E) CE2, S1D12, CA4 and S1G2 epitopes in relation to published cryo-EM structure of AD tau filaments [21]. Amino acid colour coding: white - hydrophobic, blue - positive, red - negative, green - polar, pink - zwitterion, purple - proline, yellow - cysteine. Image modified from [21]

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193