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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

Fig. 5

Correlation of antibody affinity and anti-aggregation potency – (A) Ranking the relative affinity of core binders against dGAE where a binding curve based on the immunoreactivity of scAbs was generated using average absorbance readings from 3 independent experiments. (B) BC50 values were calculated for each scAb via a 4-parameter logistic-regression model. (C) Linear regression and Pearson correlation of scAb immunoreactivity against aggregation inhibition properties in thioflavin-T assay. A strong negative correlation confirms that higher affinity scAbs have greater ability to inhibit aggregation. The correlation analysis includes all scAbs tested (n = 12); not just those in the lead panel. (D) Linear regression and Pearson correlation of scAb immunoreactivity against tau-tau immunoassay. A positive correlation confirms that higher affinity scAbs result in stronger inhibition of tau-tau aggregation. Correlation includes all scAbs tested (n = 16)

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Alzheimer's Research & Therapy

ISSN: 1758-9193