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Table 1 Baseline clinical and neurocognitive characteristics of participants

From: Amyloid deposition and its association with depressive symptoms and cognitive functions in late-life depression: a longitudinal study using amyloid-β PET images and neuropsychological measurements

Clinical Characteristics

Late-Onset Depression

Healthy Control

p

(n = 41)

(n = 20)

Gender, male (%)a

 

5 (12.2%)

 

13 (65%)

< 0.001

Age, yearsb

 

73.54 ± 5.85

 

74.25 ± 5.27

0.646

Education, yearsc

 

8.88 ± 4.05

 

11.00 ± 5.16

0.132

> 12 Yearsd

 

7 (17.1%)

 

7 (35.0%)

0.247

Suicidality measured by MINI SMd

 

4.07 ± 5.19

 

0

< 0.001

HAM-Dc

 

17.90 ± 6.00

 

3.89 ± 1.88

< 0.001

≥ 24d

 

6 (14.6%)

 

0

0.230

HAM-Ac

 

11.54 ± 4.89

 

3.94 ± 2.78

< 0.001

SFGDSc

 

6.07 ± 3.37

 

2.41 ± 2.74

0.002

≥ 8d

 

15 (36.6%)

 

1 (5%)

0.018

K-MMSEb

 

24.02 ± 5.48

 

25.39 ± 3.05

0.382

MGH-CPFQb

 

21.85 ± 5.77

 

13.65 ± 5.07

< 0.001

CGI-Sc

 

3.95 ± 0.84

 

1.06 ± 0.24

< 0.001

Amyloid-β (Global SUVR)

 

1.46 ± 0.30

 

1.42 ± 0.22

0.580

Items of Neurocognitive Tests

Mean

SD

Mean

SD

Adjusted p**

Attention; Digit Span Forward

5.08

1.73

5.89

2.00

0.033

Language & Related; S-K-BNT

8.73

3.23

11.00

2.57

< 0.001

Visuospatial; RCFT Copy

28.00

10.91

31.19

6.92

0.034

Memory

 AVLT Recall Total

27.48

8.52

28.56

7.43

< 0.001

 AVLT Delayed Recall

4.88

3.84

4.83

3.15

0.131

 AVLT Recognition

9.78

2.94

10.06

3.72

0.160

 RCFT Immediate Recall

7.61

7.66

13.22

7.80

0.004

 RCFT Delayed Recall

8.23

7.46

13.86

6.61

0.011

 RCFT Recognition

17.71

2.94

18.56

2.87

0.057

Frontal

 Contrasting Program

18.08

4.39

18.89

2.40

0.057

 GoNoGo Test

15.78

5.77

18.28

3.05

0.177

 COWAT Animal

10.46

3.31

12.56

4.36

0.004

 COWAT Phonemic Total

13.17

8.99

14.28

9.43

< 0.001

 K-CWST Word Reading Time

93.44

23.64

77.72

27.36

< 0.001

 K-CWST Color Reading Correct

57.68

28.09

71.89

21.49

0.003

 K-CWST Color Reading Error

2.95

4.68

4.72

6.99

0.031

 Digit Symbol Coding Correct

30.53

16.88

41.83

18.69

< 0.001

 K-TMT-E Part B Success Time

84.97

63.20

47.83

25.27

0.004

 K-TMT-E Part B Success Error

1.53

2.11

0.44

1.42

0.091

  1. SD Standard deviation, MINI SM The Mini-International Neuropsychiatric Interview Suicidality Module, HAM-D Hamilton Depression Rating Scale, HAM-A Hamilton Anxiety Rating Scale, SFGDS Short Form Geriatric Depression Scale, K-MMSE, Korean version of Mini-Mental Status Examination, MGH-CPFQ The Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire, CGI-S Clinical Global Impression Scale, SUVR Standardized uptake value ratio, S-K-BNT Short-Korean-Boston Naming Test, RCFT Rey Complex Figure Test, AVLT Auditory Verbal Learning Test, COWAT Controlled Oral Word Association Test, K-CWST Korean-Color Word Stroop Test, K-TMT-E Korean-Trail Making Test-Elderly’s version
  2. aChi square test was used
  3. bStudent’s t-test was used. Data are given as mean and standard deviation
  4. cMann–Whitney test was used
  5. dFisher’s exact test was used
  6. **Multiple analyses of covariance were performed to test for differences in neurocognitive test results between groups after controlling for age, sex, and years of education. The false discovery rate procedure was applied for multiple comparisons, with significance set at p < 0.05
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Alzheimer's Research & Therapy

ISSN: 1758-9193