Amyloid deposition and its association with depressive symptoms and cognitive functions in late-life depression: a longitudinal study using amyloid-β PET images and neuropsychological measurements

Kim, Kiwon; Jang, Yoo Jin; Shin, Jeong-Hyeon; Park, Mi Jin; Kim, Hyun Soo; Seong, Joon-Kyung; Jeon, Hong Jin

doi:10.1186/s13195-024-01562-0

Alzheimer's Research & Therapy

Table 4 Correlation between amyloid deposition and neurocognitive changes after three months in late-onset depression

From: Amyloid deposition and its association with depressive symptoms and cognitive functions in late-life depression: a longitudinal study using amyloid-β PET images and neuropsychological measurements

Items of Neurocognitive Tests	Structure Name	rho	p	Adjusted p^*
AVLT Delayed Recall Difference	Left Lateral Occipital Lobe	-0.475	0.004	0.090
	Left Lateral Temporal Lobe	-0.424	0.010	0.109
	Left Medial Temporal Lobe	-0.412	0.013	0.109
	Left Middle Frontal Lobe	-0.363	0.030	0.112
	Right Lateral Temporal Lobe	-0.387	0.020	0.112
	Right Medial Occipital Lobe	-0.362	0.030	0.112
	Right Posterior Cingulate	-0.345	0.039	0.128
	Right Precuneus	-0.372	0.026	0.112
RCFT Recognition Difference	Left Lateral Temporal Lobe	-0.366	0.043	0.427
Contrasting Program Difference	Right Posterior Cingulate	0.364	0.041	0.423
Contrasting Program Difference	Right Precuneus	0.410	0.020	0.423
COWAT Animal Difference	Left Lateral Temporal Lobe	-0.398	0.024	0.074
	Left Orbitofrontal Cortex	-0.374	0.035	0.076
	Left Superior Frontal Lobe	-0.357	0.045	0.078
	Left Superior Parietal Lobe	-0.376	0.034	0.076
	Right Inferior Frontal Lobe	-0.398	0.024	0.074
	Right Inferior Parietal Lobe	-0.388	0.028	0.074
	Right Lateral Occipital Lobe	-0.388	0.028	0.074
	Right Lateral Temporal Lobe	-0.429	0.014	0.074
	Right Medial Occipital Lobe	-0.418	0.017	0.074
	Right Medial Temporal Lobe	-0.420	0.017	0.074
	Right Middle Frontal Lobe	-0.367	0.039	0.078
	Right Orbitofrontal Cortex	-0.389	0.028	0.074
	Right Precuneus	-0.419	0.017	0.074
	Right Superior Frontal Lobe	-0.388	0.028	0.074
K-CWST Word Reading Time Difference	Left Inferior Frontal Lobe	-0.426	0.017	0.064
	Left Inferior Parietal Lobe	-0.439	0.014	0.064
	Left Medial Occipital Lobe	-0.436	0.014	0.064
	Left Middle Frontal Lobe	-0.399	0.026	0.064
	Left Orbitofrontal Cortex	-0.361	0.046	0.079
	Left Precuneus	-0.417	0.020	0.064
	Left Superior Parietal Lobe	-0.411	0.022	0.064
	Right Anterior Cingulate	-0.439	0.014	0.064
	Right Lateral Temporal Lobe	-0.376	0.037	0.074
	Right Medial Occipital Lobe	-0.361	0.046	0.079
	Right Orbitofrontal Cortex	-0.413	0.021	0.064
	Right Posterior Cingulate	-0.393	0.029	0.064
	Right Precuneus	-0.392	0.029	0.064
	Right Superior Frontal Lobe	-0.440	0.013	0.064
	Right Superior Parietal Lobe	-0.400	0.026	0.064

AVLT Auditory Verbal Learning Test, COWAT Controlled Oral Word Association Test, K-CWST Korean-Color Word Stroop Test, K-TMT-E Korean-Trail Making Test-Elderly’s version
^*Spearman correlational analyses were performed after adjusting for age, sex, and years of education with false discovery rate for multiple comparisons

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ISSN: 1758-9193

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