Impact of amyloid and cardiometabolic risk factors on prognostic capacity of plasma neurofilament light chain for neurodegeneration

Table 2 Impact of Aβ and cardiometabolic risk factors on associations between baseline plasma NfL and longitudinal changes in ADAS-Cog scores, hippocampal volumes, or WMH volumes

Explanatory variable	Outcome	beta	t value	p-value
Plasma NfL × Time × Aβ	ADAS-Cog score	0.004	2.797	0.005
	Hippocampal volume	-0.002	-2.922	0.004
	WMH volume	0.001	1.408	0.160
Plasma NfL × Time × Hypertension	ADAS-Cog score	0.005	3.606	< 0.001
	Hippocampal volume	-0.002	-3.814	< 0.001
	WMH volume	0.002	3.389	< 0.001
Plasma NfL × Time × DM	ADAS-Cog score	0.008	3.436	< 0.001
	Hippocampal volume	-0.001	-1.296	0.195
	WMH volume	0.001	0.861	0.390
Plasma NfL × Time × Impaired kidney function	ADAS-Cog score	-0.002	-0.597	0.551
	Hippocampal volume	-0.001	-0.480	0.632
	WMH volume	0.002	1.502	0.133
Plasma NfL × Time × Obesity	ADAS-Cog score	0.003	1.594	0.112
	Hippocampal volume	-0.002	-2.238	0.026
	WMH volume	0.002	1.898	0.058

Shown are results of linear mixed-effect models where each main explanatory variable was the three-way interaction term including baseline NfL, time, and the variable of interest (Aβ, hypertension, DM, impaired kidney function, or obesity). If the interaction term is statistically significant (p-value < 0.05), the association between plasma NfL and longitudinal changes in outcome is dependent on the status of the variable of interest (Aβ, hypertension, DM, impaired kidney function, or obesity)
Of outcome variables, ADAS-Cog score and WMH volume were square root transformed due to non-normal distribution
Continuous variables except for time were standardized to z-scores
All models were adjusted for the following covariates: baseline age, sex, years of education, APOE ε4 allele count, ever smoking, alcohol abuse, SGDS, Aβ status, hypertension, DM, obesity, impaired kidney function, and baseline cognitive status (MCI or CU)
Florbetapir PET SUVR 1.11 or over was regarded as Aβ ( +) status
Abbreviations: Aβ amyloid-β, ADAS-Cog Alzheimer’s Disease Assessment Scale-Cognitive subscale, APOE apolipoprotein E, CU cognitively unimpaired, DM diabetes mellitus, MCI mild cognitive impairment, NfL neurofilament light chain, PET positron emission tomography, SGDS Short form of Geriatric Depression Scale, SUVR standard uptake value ratio, WMH white matter hyperintensity

ISSN: 1758-9193