Impact of amyloid and cardiometabolic risk factors on prognostic capacity of plasma neurofilament light chain for neurodegeneration

Table 3 Impact of Aβ on association between baseline plasma NfL and longitudinal cognition/brain structure, stratified by baseline cognitive status (MCI vs CU)

Explanatory variable	Outcome	beta	t value	p-value
Plasma NfL × Time × Aβ
In MCI participants (n = 441)	ADAS-Cog score	0.0004	0.173	0.863
	Hippocampal volume	-0.001	-0.954	0.341
	WMH volume	-0.001	-1.009	0.314
In CU participants (n = 279)	ADAS-Cog score	0.005	2.724	0.007
	Hippocampal volume	-0.002	-1.519	0.130
	WMH volume	0.003	2.117	0.036

Shown are results of linear mixed-effect models where the main explanatory variable was the three-way interaction term, including baseline plasma NfL, time, and Aβ, analyzed using the entire dataset and stratified by baseline cognitive status (MCI or CU). If the interaction term is statistically significant (p-value < 0.05), the association between plasma NfL and longitudinal changes in outcome is dependent on the status of Aβ
Of outcome variables, ADAS-Cog score and WMH volume were square root transformed due to non-normal distribution
All continuous variables were standardized to z-scores for comparison between models
The model using entire participants was adjusted for the following covariates: baseline age, sex, years of education, APOE ε4 allele count, ever smoking, alcohol abuse, SGDS, Aβ status, hypertension, DM, obesity, impaired kidney function, and baseline cognitive status (MCI or CU). Models stratified by MCI or CU were adjusted for same covariates except for baseline cognitive status
Abbreviations: Aβ amyloid-β, ADAS-Cog Alzheimer’s Disease Assessment Scale-Cognitive subscale, APOE apolipoprotein E, CU cognitively unimpaired, DM diabetes mellitus, MCI mild cognitive impairment, NfL neurofilament light chain, PET positron emission tomography, SGDS Short form of Geriatric Depression Scale, SUVR standard uptake value ratio, WMH white matter hyperintensity

ISSN: 1758-9193