Table 3 Estimated mean change in the primary outcome and in other neuropsychological assessment
Change from the baseline to the end of intervention | Change from the baseline to 3-month follow-up | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
tACS group, mean change (95%CI) | Sham group, mean change (95%CI) | standardized coefficients for group*time | Model Fit Indices (AIC) | P value | tACS group, mean change (95%CI) | Sham group, mean change (95%CI) | Standardized Coefficients for group*time | Model Fit Indices (AIC) | P value | |
ADAS-Cog* | -1.652 (-4.882 to 1.578) | 0.130 (-3.324 to 3.585) | -0.320 | 570.32 | 0.449 | -0.741 (-3.834 to 2.352) | 0.085 (-3.875 to 4.044) | -0.148 | 526.808 | 0.739 |
MMSE* | 3.000 (1.022 to 4.978) | 0.043 (-2.037 to 2.124) | 0.839 | 482.45 | 0.041 | 1.041 (-0.928 to 3.010) | 0.162 (-2.269 to 2.593) | 0.250 | 450.277 | 0.569 |
MoCA# | 2.217 (-0.010 to 4.445) | 0.348 (-2.009 to 2.705) | - | - | 0.025 | 0.859 (-1.425 to 3.143) | 1.150 (-1.694 to 3.993) | - | - | 0.322 |
WHO-UCLA AVLT | ||||||||||
Immediate recall* | 1.652 (-2.310 to 5.614) | -1.348 (-4.131 to 1.435) | 0.520 | 574.47 | 0.215 | 1.027 (-2.949 to 5.043) | -0.493 (-3.477 to 2.492) | 0.269 | 528.483 | 0.544 |
Delayed recall# | 1.870 (0.058 to 3.681) | -0.130 (-0.915 to 0.654) | - | - | 0.027 | 0.909 (-0.535 to 2.352) | 0.056 (-0.861 to 0.973) | - | - | 0.220 |
Recognition# | 0.478 (-1.693 to 2.650) | 0.543 (-1.391 to 2.608) | - | - | 0.439 | -1.039 (-3.151 to 1.072) | 0.014 (-1.912 to 1.941) | - | - | 0.611 |
Digit span forward# | 0.174 (-0.604 to 0.951) | 0.043 (-0.597 to 0.684) | - | - | 0.669 | 0.095 (-0.834 to 1.025) | -0.058 (-0.789 to 0.673) | - | - | 0.872 |
Digit span backward# | -0.043 (-0.669 to 0.582) | 0.261 (-0.559 to 1.081) | - | - | 0.315 | 0.110 (-0.462 to 0.682) | 0.290 (-0.604 to 1.184) | - | - | 0.618 |
BNT# | 2.130 (0.217 to 4.044) | 1.478 (-1.556 to 4.512) | - | - | 0.229 | 0.460 (-1.899 to 2.818) | 0.483 (-2.762 to 3.728) | - | - | 0.531 |
TMT B-A* | -8.565 (-57.889 to 40.759) | -40.391 (-89.201 to 8.418) | 0.383 | 1043.06 | 0.358 | 1.876 (-49.466 to 53.217) | -20.542 (-70.301 to 29.217) | 0.277 | 947.73 | 0.535 |
ADL# | -0.230 (-2.312 to 1.853) | 0.095 (-2.722 to 2.911) | - | - | 0.161 | 0.605 (-1.466 to 2.676) | -0.531 (-3.162 to 2.100) | - | - | 0.366 |
NPI# | -0.947 (-4.069 to 2.174) | 0.085 (-7.236 to 7.406) | - | - | 0.998 | -0.095 (-3.779 to 3.589) | 2.686 (-5.384 to 10.756) | - | - | 0.162 |
GDS# | -0.573 (-3.258 to 2.111) | -1.409 (-4.015 to 1.197) | - | - | 0.884 | -1.439 (-4.391 to 1.509) | -0.581 (-3.374 to 2.212) | - | - | 0.576 |