Fig. 1
From: Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease
aEOAD and aLOAD group differences and to respective controls in medial temporal lobe subfield volume/thickness. The figure shows the group comparisons for all medial temporal lobe subfield measures, indicating significant differences of amnestic AD groups to respective controls, but limited differences between aEOAD and aLOAD. Separate ANOVAs were performed for each comparison. Post-hoc comparisons focused on three group differences: young controls vs. aEOAD, older controls vs. aLOAD, and aEOAD vs. aLOAD. Significant differences are shown using FDR-corrected p-values; *=pFDR < .05; **=pFDR < .001. The ROI measures were z-scored based on young cognitively unimpaired individuals (< 40, CSF Aβ42/40 negative). All analyses included sex as a covariate. Results for the neocortical regions are included in the supplementary information. Non-amnestic individuals were not considered for these analyses. Abbreviations: aEOAD = amnestic early-onset Alzheimer’s Disease; aLOAD = amnestic late-onset Alzheimer’s disease; OCU = older cognitively unimpaired controls; YCU = younger cognitively unimpaired controls