Fig. 2
From: Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease
aEOAD and aLOAD group differences and to respective controls in AD pathologies and co-pathologies. The figure shows the group comparisons for all AD and non-AD pathologies, indicating significant differences of amnestic AD groups to respective controls, but only a significant difference in WMH volume between aEOAD and aLOAD. Separate ANOVAs were performed for each pathology. Post-hoc comparisons focused on three group differences: younger controls vs. EOAD, older controls vs. aLOAD, and aEOAD vs. aLOAD. Significant differences are shown using FDR-corrected p-values; *=pFDR < .05; **=pFDR < .001. aHC/PHC ratio is an approximation of TDP-43 pathology. All analyses included sex as a covariate. Non-amnestic individuals were not considered for these analyses. Abbreviations: Aβ = amyloid-beta; aHC/PHC ratio = ratio of anterior hippocampus and parahippocampal cortex; aEOAD = amnestic early-onset Alzheimer’s Disease; aLOAD = amnestic late-onset Alzheimer’s disease; CSF = cerebrospinal fluid; PET = positron emission tomography; SUVR = standardized uptake value ratio; OCU = older cognitively unimpaired controls; WMH = white matter hyperintensities; YCU = younger cognitively unimpaired controls