Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease

Table 1 Characteristics of the amnestic EOAD and LOAD groups and respective controls

	YCU	OCU	aEOAD	aLOAD	Total	p-value YCU-aEOAD	p-value OCU-aLOAD	p-value aEOAD-aLOAD
N	188	151	41	154	534	-	-	-
Diagnosis						-	-	0.713
CU	188 (100)	151 (100)	0 (0)	0 (0)	339 (63.5)
MCI	0 (0)	0 (0)	16 (39.0)	65 (42.2)	81 (15.2)
AD	0 (0)	0 (0)	25 (61.0)	89 (57.8)	114 (21.3)
Sex (female)	103 (54.8)	99 (65.5)	20 (48.8)	82 (53.2)	304 (56.9)	0.485	0.029	0.611
Age	58.6 ± 4.89	77.3 ± 3.38	61.0 ± 4.82	76.2 ± 3.92	69.2 ± 9.76	0.005	0.008	-
Range	51.0–69.0	70.3–85.0	50.9–69.4^a	70.1–85.1	50.9–85.1
Education (years)	13.2 ± 3.12	12.4 ± 3.74	14.1 ± 3.33	12.5 ± 4.79	12.8 ± 3.86	0.116	0.816	0.052
Missing	2 (1.1)	0 (0.0)	1 (2.4)	6 (3.9)	9 (1.7)
*APOE-*ε4allele+	85 (45.2)	29 (19.2)	25 (61.0)	114 (74.0)	253 (47.4)	0.066	< 0.001	0.116
CSF Aβ42/40 + ^b	0 (0.0)	0 (0.0)	41 (100)	154 (100)	195 (36.5)	-	-	-
MMSE	29.2 ± 0.92	28.8 ± 1.20	24.6 ± 3.22	24.4 ± 2.53	27.3 ± 2.87	< 0.001	< 0.001	0.622

Continuous variables are displayed as mean ± SD. Categorical variables are displayed as n (%). Bold p-values are statistically significant at p < 0.05
Abbreviations Aβ = amyloid-beta; AD = Alzheimer’s disease; aEOAD = amnestic early-onset cognitive impairment, aLOAD = amnestic late-onset cognitive impairment; APOE = apolipoprotein E; CU = cognitively unimpaired; CSF = cerebrospinal fluid; MCI = mild cognitive impairment; MMSE = Mini-Mental State Examination; OCU = older cognitively unimpaired controls; SD = standard deviation; YCU = younger cognitively unimpaired controls
^a individuals who reported an age-of-onset under 65 were included in the EOAD group. ^b Aβ positivity: <0.08 on CSF Aβ42/40 ratio. The demographic information of the non-amnestic EOAD and LOAD individuals can be found in sTable S3 and are not included in the total of this table

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