Fig. 2

Plasma concentrations of Aβ isoforms in APPswe, repeated-measures. Plasma concentrations from repeated-measures of (A) Aβ1–38, (B) Aβ1–40, (C) Aβ1–42 and (D) Aβ1–42/ 1–40 ratio. Trajectories indicating fitting of mixed-effects data with confidence bands for MC (23 samples) and NC (49 samples) at the group level, as well as repeated-measures at the individual level. Two individuals had symptom onset during follow-up. The dotted line at 54 years of age represents the mean age at onset in the APPswe family. NC = Non-carriers, MC = Mutation carriers