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Table 3 Mixed-effects models of plasma Aβ isoforms in PSEN1 (p.H163Y) MC vs. NC

From: Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease

 

Age

Mut status

Mut status*Age

Estimate [SE]

Estimate [SE]

Estimate [SE]

Aβ1–38 (pg/mL)

0.134 [0.044]**

ns

ns

Aβ1–40 (pg/mL)

1.44[0.434]**

ns

ns

Aβ1–42 (pg/mL)

ns

ns

ns

Aβ1–42/1–40

-507*10^(-4) [188*10^(-4)]**

ns

ns

  1. Mixed-effects models of repeated-measures data in LC-MS/MS analysis. 69 plasma samples were included from PSEN1 (p.H163Y) MC (n = 5, 20 samples) and NC (n = 29, 49 samples). Table showing estimates, the standard error (SE) within brackets and statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001). Mut status = Mutation status, here mutation carriers compared to non-carriers. Age was centered to 52 years, the mean age at onset in the PSEN1 family. All models were corrected for APOE ɛ4 status and sex
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Alzheimer's Research & Therapy

ISSN: 1758-9193