Fig. 3

Association between localized QSM and longitudinal domain-specific cognitive score changes. A, B Trajectory plots illustrate the impact of baseline QSM on the change in longitudinal attention and visuospatial function. The annual rate of domain-specific cognitive decline was calculated for each individual and plotted against the baseline localized QSM values. Estimated cognitive trajectories with 95% confidence intervals (CIs) are displayed. The model is adjusted for sex, age, years of education, smoking, drinking, hypertension, diabetes, and hyperlipidemia, eTIV and cortical thickness of each ROI (Supplemental Table 7; Model 3). Abbreviations: AD = Alzheimer's disease; AG = Aging; QSM = quantitative susceptibility mapping