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Table 3 Association between localized QSM and longitudinal global cognition

From: Brain Iron in signature regions relating to cognitive aging in older adults: the Taizhou Imaging Study

 

change in ZMMSE

change in ZMoCA

 

\(\:\beta\:\)(95% CI)

P

\(\:\beta\:\)(95% CI)

P

Cortical QSM

 Model 1

-0.162 (-0.488, 0.164)

0.329

-0.433 (-0.758, -0.109)

0.009

 Model 2

-0.165 (-0.495, 0.165)

0.326

-0.440 (-0.769, -0.112)

0.009

 Model 3

-0.164 (-0.495, 0.166)

0.329

-0.441 (-0.770, -0.112)

0.009

AG-specific signature QSM

 Model 1

-0.220 (-0.544, 0.104)

0.184

-0.526 (-0.847, -0.204)

0.001

 Model 2

-0.222 (-0.549, 0.105)

0.182

-0.527 (-0.851, -0.202)

0.002

 Model 3

-0.221 (-0.548, 0.106)

0.185

-0.526 (-0.850, -0.201)

0.002

AD signature QSM

 Model 1

-0.087 (-0.411, 0.236)

0.595

-0.354 (-0.677, -0.032)

0.031

 Model 2

-0.090 (-0.419, 0.239)

0.592

-0.365 (-0.693, -0.037)

0.029

 Model 3

-0.092 (-0.421, 0.238)

0.585

-0.364 (-0.692, -0.035)

0.030

  1. Standardized Beta coefficient values represent a one unit change in global cognition z-score per 1 years with a one PPB change in QSM
  2. Model 1 was adjusted for sex, age, years of education and eTIV
  3. Model 2 was additionally adjusted smoking, drinking, hypertension, diabetes, and hyperlipidemia
  4. Model 3 was additionally adjusted cortical thickness of each ROI
  5. Abbreviations: AD = Alzheimer’s disease; AG = Aging; MMSE = Mini-Mental State Examination; MoCA = Montreal Cognitive Assessment; QSM = quantitative susceptibility mapping
  6. Benjamini-Hochberg FDR corrected P < 0.05 are shown bold
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Alzheimer's Research & Therapy

ISSN: 1758-9193