Network dynamics-based subtyping of Alzheimer’s disease with microglial genetic risk factors

Table 1 Risk genes included in the network and information used risk variants

Gene	SNP	p-value	Odds ratio (beta)	Risk allele	Risk allele frequency	Reference	Activation/ Inhibition	Reference for Activation/ Inhibition
ABCA7	rs12151021	2E-37	1.1	A	0.336	[48]	Inhibition	[54]
ABI3	rs616338	3E-14	1.32	T	0.012	[48]	Inhibition	[55]
APOE	rs429358	2E-30	5.24	C	0.210	[49]	Inhibition	[56]
BIN1	rs6733839	6E-118	1.17	T	0.389	[48]	Activation	[57]
CASS4	rs7274581	3E-8	1.36	T	0.917	[50]	Activation	[58]
CD2AP	rs7767350	8E-22	1.08	T	0.271	[48]	Activation	[59]
CD33	rs3865444	2E-9	1.1	C	0.7	[51]	Inhibition	[60]
CLU	rs9331896	3E-25	1.16	T	0.621	[50]	Inhibition	[61]
HLA_DR	rs9271192	3E-12	1.11	C	0.276	[50]	Activation	[62]
INPP5D	rs10933431	4E-18	0.93	G	0.234	[48]	Activation	[63]
MEF2C	rs190982	2E-8	1.08	A	0.592	[50]	Inhibition	[64]
MS4A	rs1582763	4E-42	0.91	A	0.371	[48]	Activation	[65]
PICALM	rs561655	7E-11	1.15	A	0.66	[51]	Activation	[66]
PILRA	rs1859788	2E-15	-7.93z	A	0.31	[52]	Inhibition	[67]
PLCG	rs12446759	1E-13	0.95	G	0.43	[48]	Activation	[68]
PTK2B	rs73223431	4E-22	1.07	T	0.369	[48]	Inhibition	[69]
RIN3	rs71430765	1E-6	N/A	G	0.163	[53]	Inhibition	[70]
SORL1	rs11218343	1E-21	0.84	C	0.039	[48]	Activation	[71]
SPI1	rs10437655	5E-14	1.06	A	0.399	[48]	Activation	[72]
TREM2	rs143332484	3E-25	1.41	T	0.013	[48]	Inhibition	[73]

ISSN: 1758-9193