Table 2 Optimal single and double targets to restore a normal phenotype
From: Network dynamics-based subtyping of Alzheimer’s disease with microglial genetic risk factors
Target 1 | Target 1 direction | Target 2 | Target 2 direction | |
|---|---|---|---|---|
Subtype 0_single | PICALM | Inhibition | ||
Subtype 0_double | PICALM | Inhibition | LAT2 | Inhibition |
Subtype 1_single | PI3K | Inhibition | ||
Subtype 1_double | GSK3b | Inhibition | INPP5D | Inhibition |
Subtype 2_single | AKT | Inhibition | ||
Subtype 2_double | ABCA7 | Activation | MEF2C | Activation |
Subtype 3_single | MEF2C | Activation | ||
Subtype 3_double | MEF2C | Activation | PICALM | Inhibition |
Subtype 4_single | MS4A | Activation | ||
Subtype 4_double | PICALM | Inhibition | PTK2B | Activation |
Subtype 5_single | MEF2C | Activation | ||
Subtype 5_double | MEF2C | Activation | PICALM | Inhibition |
Subtype 6_single | LAT2 | Inhibition | ||
Subtype 6_double | CD33 | Activation | LAT2 | Inhibition |
Subtype 7_single | CD2AP | Inhibition | ||
Subtype 7_double | BHLHE41 | Activation | RIN3 | Inhibition |