Table 4 Maximal change from baseline in plasma Aβ42 concentration after a single intravenous dose of SHR-1707

2 mg/kg

6 mg/kg

20 mg/kg

40 mg/kg

60 mg/kg

Study CHN Part 1

Subject No.

10

8

8

8

8

8

Baseline, pg/mL

16.2 (1.7)

15.4 (1.6)

14.3 (2.4)

15.9 (1.9)

17.5 (0.8)

17.8 (2.0)

Maximal change

from baseline, pg/mL

1.3 (2.3)

9.8 (3.6)

23.2 (8.3)

65.6 (10.0)

109.8 (53.2)

173.2 (62.4)

Study CHN Part 2

Subject No.

4

–

–

8

–

–

Baseline, pg/mL

13.2 (4.8)

–

–

20.1 (4.1)

–

–

Maximal change

from baseline, pg/mL

6.7 (7.2)

–

–

64.4 (9.5)

–

–

Study AUS^**

Subject No.

6

8

–

8

–

8

Baseline, pg/mL

14.1 (2.7)

15.0 (1.0)

–

13.7 (2.4)

–

13.9 (5.4)

Maximal change

from baseline, pg/mL

1.0 (2.7)

7.6 (2.2)

–

61.6 (13.8)

–

119.5 (17.5)