Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies

Planas-Ballvé, Anna; Rios, Jose; Gea, Mireia; Rabaneda-Lombarte, Neus; Ispierto, Lourdes; Grau, Laia; Jiménez, Marta; Cáceres, Cynthia; Martínez, Sílvia; Beyer, Katrin; Álvarez, Ramiro; Pastor, Pau; Vilas, Dolores

doi:10.1186/s13195-024-01590-w

Alzheimer's Research & Therapy

Table 2 Sonographic characteristics – bedside analysis

From: Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies

	DLB (n = 22)	AD (n = 19)	PD (n = 22)	Controls (n = 27)	p-value^A	p-value DLB vs controls^B	p-value DLB vs AD^B	p-value DLB vs PD^B	p-value AD vs controls^B	p-value PD vs controls^B	p-value AD vs PD^B
Right SN area in cm², median (IQR)	0.20 (0.14–0.25)	0.13 (0.10–0.15)	0.19 (0.16–0.26)	0.11 (0.08–0.12)	< 0.001	< 0.001	0.023	0.584	0.050	< 0.001	0.002
Left SN area in cm², median (IQR)	0.23 (0.19–0.27)	0.11 (0.09–0.13)	0.23 (0.16–0.3)	0.11 (0.09–0.13)	< 0.001	< 0.001	< 0.001	0.712	0.905	< 0.001	< 0.001
SN hyperechogenicity, n(%)	16 (72.73)	2 (10.53)	18 (81.82)	2 (7,41)	< 0.001	< 0.001	< 0.001	0.721	1.000	0.000	< 0.001
Bilateral SN hyperchogenicity, n(%)	11 (50)	1 (5.26)	6 (27.27)	0 (0)	< 0.001	< 0.001	0.002	0.215	0.413	0.005	0.099
IIIv size in cm, median (IQR)	0.68 (0.52–0.83)	0.73 (0.58–0.92)	0.52 (0.31–0.77)	0.51 (0.42–0.72)	0.017	0.051	0.367	0.091	0.009	0.719	0.015
Widened IIIv, n(%)	2 (9.09)	5 (26.31)	0	2 (7.41)	0.058	1.000	0.412	0.214	0.217	0.492	0.017
Frontal right horn of LV size in cm, median (IQR)	1.89 (1.66–2.10)	1.92 (1.78–2.22)	1.77 (1.55–1.88)	1.63 (1.49–1.91)	0.002	0.004	0.271	0.028	0.002	0.420	0.010
Widened right horn of LV, n(%)	8 (36.36)	7 (36.84)	2 (9.09)	5 (18.51)	0.031	0.199	0.741	0.030	0.153	0.418	0.017
Frontal left horn of LV size in cm, median (IQR)	1.99 (1.85–2.07)	1.71 (1.57–2.09)	1.76 (1.64–1.92)	1.76 (1.62–1.9)	0.047	0.013	0.310	0.003	0.777	0.995	0.726
Widened left horn of LV, n(%)	9 (40.9)	7 (36.84)	3 (13.63)	5 (18.51)	0.091	0.192	1.000	0.082	0.164	0.700	0.062

DLB Dementia with Lewy bodies, PD Parkinson’s disease, AD Alzheimer’s disease, SN Substantia Nigra, IIIv Third ventricle, LV Lateral ventricle
^AFisher’s Exact test for qualitative variables or Kruskal–Wallis test for quantitative variables
^BFisher’s Exact test for qualitative variables or Mann–Whitney U Test for quantitative variables

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ISSN: 1758-9193

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