Fig. 2

Association of plasma NfL and confounding variables with MMSE over time in the whole cohort, neurodegenerative conditions group and non-neurodegenerative conditions group

(A) Factors associated with MMSE in cross-sectional analysis in the whole cohort. (B) Factors associated with MMSE change over time in the whole cohort (C) Factors associated with baseline MMSE in the neurodegenerative condition group. (D) Factors associated with MMSE decline in the neurodegenerative condition group. (E) Factors associated with baseline MMSE in the non-degenerative condition group. (F) Factors associated with MMSE decline in the non-degenerative group.

Standardized estimates with the corresponding 95% CI were plotted for the association of baseline plasma NfL levels and confounding variables with MMSE scores at baseline (cross-sectional) and during follow-up (longitudinal) in the different groups.

All models represented are linear mixed models with fixed effects on plasma NfL, age, education level, body mass index and glomerular filtration rate. Random intercepts and slopes were included. All variables were log-transformed prior to analysis.