Table 2 a. Cross-sectional association of plasma NfL, age, education levels, GFR and BMI with neurocognitive functions and neuroimaging markers in the global population

Cognitive z scores

Global cognition

-1.28 (-1.81 ; -0.75)

< 0.001

0.26 (-1.88 ; 2.40)

0.813

3.42 (2.71 ; 4.12)

< 0.001

-0.44 (-1.03 ; 0.15 )

0.140

-0.27 (-0.97 ; 0.44)

0.455

Memory

-1.48 (-2.38 ; -0.59)

0.001

-3.47 (-7.13 ; 0.19)

0.063

2.58 (1.35 ; 3.83)

< 0.001

-0.37 (-1.35 ; 0.62)

0.465

0.22 (-0.94 ; 1.39)

0.708

Langage

-1.72 (-2.49 ; -0.95)

< 0.001

1.71 (-1.43 ; 4.85)

0.285

2.93 (1.89 ; 3.96)

< 0.001

-0.30 (-1.15 ; 0.54)

0.478

-0.18 (-1.20 ; 0.84)

0.729

Visuospatial

-1.14 (-2.54 ; 0.25)

0.108

-0.82 (-6.41 ; 4.77)

0.772

4.66 (2.71 ; 6.61)

< 0.001

-1.52 (-2.97 ; -0.05)

0.042

-1.92 (-3.76 ; -0.08)

0.041

Praxis

-2.02 (-2.91 ; -1.13)

< 0.001

5.18 (1.50 ; 8.85)

0.006

3.26 (2.06 ; 4.47)

< 0.001

0.19 (-0.82 ; 1.19)

0.716

0.21 (-0.99 ; 1.41)

0.734

Executive functions

-0.81 (-1.30 ; -0.37)

0.001

-0.29 (-2.23 ; 1.65)

0.770

3.49 (2.85 ; 4.13)

< 0.001

-0.30 (-0.83 ; 0.23)

0.270

0.16 (-0.47 ; 0.80)

0.613

Attention

-0.55 (-1.16 ; 0.06)

0.079

-0.93 (-3.33 ; 1.46)

0.443

3.29 (2.5 ; 4.08)

< 0.001

-0.50 (-1.15 ; 0.15)

0.134

-0.57 (-1.36 ; 0.22)

0.154

Neuroimaging markers

White matters hyperintensities (Fazekas scale)

0.63 (0.11 ; 1.15)

0.02

4.46 (2.35 ; 6.60)

< 0.001

0.68 (-0.01 ; 1.38)

0.053

-0.32 (-0.89 ; 0.25)

0.26

0.54 (-0.17 ; 1.24)

0.14

Hippocampal atrophy ( Scheltens scale, mean)

1.31 (0.73 ; 1.90)

< 0.001

2.75 (0.36 ; 5.14)

0.02

-0.41 (-1.20 ; 0.39)

0.31

0.11 (-0.59 ; 0.81)

0.76

-0.23 (-1.03 ; 0.58)

0.57