Table 2 b. Cross-sectional association of plasma NfL, age, education levels, GFR and BMI with neurocognitive functions and neuroimaging markers across diagnosis

Cognitive z scores

Global cognition

-1.13 (-1.67 ; -0.59)

< 0.001

-0.89 (-1.52 ; -0.25)

0.006

-0.88 (-1.43 ; -0.33)

0.002

-0.80 (-1.38 ; -0.22)

0.007

-0.37 (-1.05 ; 0.32)

0.292

Memory

-1.29 (-2.17 ; -0.42)

0.004

-0.26 (-1.28 ; 0.75)

0.608

-0.53 (-1.42 ; 0. 36)

0.239

-0.65 (-1.59 ; 0.28)

0.167

0.19 (-0.91 ; 1.29)

0.728

Langage

-1.56 (-2.37 ; -0.74)

< 0.001

-1.28 (-2.22 ; -0.33)

0.008

-1.52 (-2.35 ; -0.69)

< 0.001

-1.30 (-2.17 ; -0.43)

0.003

-1.06 (-2.08 ; -0.04)

0.042

Visuospatial

-1.09 (-2.54 ; 0.35)

0.137

-0.95 (-2.59 ; 0.68)

0.253

-0.58 (-2.01 ; 0.86)

0.432

-0.36 (-1.92 ; 1.20)

0.649

0.05 (-1.70 ; 1.81)

0.95

Praxis

-1.81 (-2.74 ; -0.87)

< 0.001

-1.60 (-2.70 ; -0.50)

0.004

-1.79 (-2.73 ; -0.84)

< 0.001

-1.63 (-2.64 ; -0.63)

0.001

-1.12 (-2.29 ; 0.63)

0.063

Executive functions

-0.71 (-1.21 ; -0.211)

0.005

-0.58 (-1.16 ; -0.002)

0.049

-0.49 (-1.01 ; 0.02)

0.058

-0.49 (-1.03 ; 0.05)

0.074

-0.15 (-0.78 ; 0.48)

0.635

Attention

-0.6 (-1.24 ; 0.05)

0.069

-0.81 (-1.55 ; -0.08)

0.030

-0.32 (-0.96 ; 0.32)

0.328

-0.42 (-1.12 ; 0.28)

0.241

-0.27 (-1.07 ; 0.52)

0.500

Neuroimaging outcomes

White matters hyperintensities (Fazekas scale)

0.62 (0.08 ; 1.17)

0.026

0.53 (-0.11 ; 1.17)

0.101

0.44 (-0.12 ; 1.01)

0.120

0.78 (0.22 ; 1.35)

0.007

0.56 (-0.12 ; 1.24)

0.108

Hippocampal atrophy (Scheltens scale, mean)

1.16 (0.55 ; 1.77)

< 0.001

1.04 (0.32 ; 1.75)

0.005

1.35 (0.73 ; 1.96)

< 0.001

0.91 (0.29 ; 1.54)

0.004

0.81 (0.04 ; 1.57)

0.039