Table 3 Association of plasma NfL and covariates with longitudinal MMSE in the global population. Linear mixed-effects model with longitudinal MMSE as the outcome, including plasma NfL levels (log) added to relevant covariates: age (log), GFR (glomerular filtration rate, CKD-EPI, log), education levels (years, log), body mass index (kg/m², log) and baseline MMSE (log). Random intercepts and slopes were included
Predictors | Estimates | CI | P value |
|---|---|---|---|
Plasma NfL (log) | -5.27 | (-7.60 ; -2.94) | < 0.001 |
Age (log) | 2.78 | (-6.76 ; 12.33) | 0.568 |
Education levels (log, years) | 11.27 | (8.19 ; 14.36) | < 0.001 |
GFR (CKD-EPI, log) | -2.25 | (-4.74 ; 0.24) | 0.076 |
Body mass index (kg /m², log) | 0.63 | (-2.43 ; 3.68) | 0.687 |
Plasma NfL (log) x Time | -0.15 | (-0.26 ; -0.04) | 0.006 |
Age (log) x Time | -0.30 | (-0.72 ; 0.13) | 0.171 |
Education levels (log, years) x Time | 0.03 | ( -0.11 ; 0.17) | 0.643 |
GFR (CKD-EPI, log) x Time | -0.10 | (-0.21 ; 0.01) | 0.089 |
Body mass index (kg /m², log) x Time | 0.08 | (-0.06 ; 0.21) | 0.269 |
Baseline MMSE (log) x Time | -0.08 | (-0.20 ; 0.03) | 0.155 |
Random Effets | |||
σ² | 3.96 | ||
τ00 ID | 11.03 | ||
τ11 IDxTime | 0.02 | ||
ρ01 ID | 0.62 | ||
ICC | 0.87 | ||
Observations | 865 | ||
Marginal R² / Conditional R² | 0.210 / 0.896 | ||