Table 4 Association of plasma NfL with longitudinal MMSE in the non-neurodegenerative and neurodegenerative groups

Predictors

Estimates

CI 95%

P

Estimates

CI 95%

P

Plasma NfL (log)

-1.16

(-3.95 ; 1.63)

0.412

-5.66

(-8.87 ; -2.46)

0.001

Age (log)

-4.99

(-19.28 ; 9.3)

0.492

13.86

(1.93 ; 25.79)

0.001

Education levels (log, years)

9.99

(5.70 ; 14.29)

< 0.001

12.45

(8.74 ; 16.15)

< 0.001

Glomerular filtration rate (CKD-EPI, log)

-1.15

(-5.16 ; 2.85)

0.572

-2.60

(-5.53 ; 0.34)

0.083

Body mass index (kg/m², log)

-1.89

(-6.20 ; 2.43)

0.389

0.03

(-3.65 ; 3.71)

0.986

Plasma NfL (log) x Time

0.00

(-0.11 ; 0.10)

0.987

-0.21

( -0.37 ; − 0.06)

0.007

Age (log) x Time

-0.13

(-0.62 ; 0.36)

0.608

0.02

( -0.55 ; 0.60)

0.936

Education level (log, years) x Time

-0.00

( -0.16 ; 0.15)

0.959

0.15

( -0.04 ; 0.33)

0.115

Glomerular filtration rate (CKD-EPI, log) x Time

-0.03

( -0.17 ; 0.10)

0.646

-0.12

( -0.26 ; 0.02)

0.093

Body mass index (kg/m², log) x Time

-0.07

( -0.22 ; 0.08)

0.345

0.07

( -0.11 ; 0.24)

0.452

Baseline MMSE (log) x Time

-0.20

(-0.41 ; 0.01)

0.056

-0.17

(-0.31 ; -0.03)

0.017

Random Effects

σ²

1.99

4.48

τ₀₀

6.20 _ID

10.87 _ID

τ₁₁

0.00 _ID.Time

0.02 _ID.Time

ρ₀₁

0.51 _ID

0.66 _ID

ICC

0.85

0.86

Observations

216

649

Marginal R² / Conditional R²

0.195 / 0.875

0.247 / 0.897