Fig. 2

Cardiovascular effects of lower CETP level/activity on cardiovascular disease estimated through cis Mendelian randomization using three distinct weighting strategies

The MR effects are estimated by alternatingly selecting instruments based on the genetic association with lower CETP concentration (μg/mL), higher Apolipoprotein-A1 (Apo-A1 in g/L), and lower Apolipoprotein-B (Apo- B in g/L). The estimated odds ratio (OR) is indicated by a circle if the p-value was smaller than 0.05/29, or by a star otherwise, with the horizontal bars representing 95% confidence intervals (95%CI), a neutral effect of 1 is indicated by the dashed vertical line. Abbreviations: CHD, coronary heart disease; AF, atrial fibrillation; HF, heart failure; AAA, abdominal aortic aneurysm. Please see Supplementary Table S1 for the full results, and Table S2 for the source data and sample size